Tobacco plant can produce anti-malaria drug
Although tobacco in the form of cigarettes is generally recognized as being a killer of millions, the plant has been used by Hebrew University researchers to produce an effective anti-malaria drug.
A genetically engineered form of artemisinin, a natural compound that produces large quantities of the anti-malaria drug - was announced Sunday by the Yissum Research Development Company - the Hebrew University of Jerusalem’s technology transfer company. The biosynthesis method - a novel way of producing Artemisia annua, which is naturally produced by sweet wormwood plants - was developed by Prof. Alexander Vainstein and the research was published as a letter in the latest issue of the journal Nature Biotechnology.
Combating malaria is one of the eight Millennium Development Goals described in the UN Millennium Declaration signed by all UN members 11 years ago. An important way to control the deadly parasitic disease that affects mostly the Third World is prompt and effective treatment with artemisinin-based combination therapies.
But low-cost artemisininbased drugs are in short supply because of the high cost of obtaining the natural or chemically synthesized drug. Despite extensive efforts made in the last decade in metabolic engineering of the drug in both microbial and heterologous plant systems, no one has been able to produce artemisinin itself.
Until now.