re: #51 kirkspencer
You could make similar arguments for detonations in Long Beach in CA or Upper NY Harbor - like say just north of the Verrazano Bridge on the East Coast. Beyond the initial damage and casualties, you’ve wrecked major port access for shipping and could cause significant delays in goods being delivered. Plus fear of radioactive contamination for a significant period of time.
Or, place it closer to the refineries in say Texas City or Newark/Linden/Elizabeth NJ cause cause a nightmare that would make the Sandy gas crisis look downright trite.