No current missile defense technology is going stop a Topol-M:

According to Russia the missile is designed to be immune to any current or planned U.S. missile defense system.[19] It is claimed to be capable of making evasive maneuvers to avoid a kill by terminal phase interceptors, and carries targeting countermeasures and decoys. It is shielded against radiation, EMP, nuclear explosions at distances over 500 meters, and is designed to survive a hit from any laser technology.[20]