New antibiotics developed from frog skin
The fight against superbugs has taken a leap forward thanks to the discovery that powerful new antibiotics could come from frogs.
Scientists have long known that the skin of frogs contains plenty of powerful germ-fighting substances because of the hostile environments they exist in.
But the substances are also often poisonous to humans.
Now a team at the United Aran Emirates University have worked out a way of modifying the chemicals to remove their harmful side-effects.
They have already identified 100 new antibiotics including one that could fight the hospital superbug methicillin-resistant Staphylococcus aureus (MRSA) bacteria.
Frog skin is an excellent potential source of such antibiotic agents,” said Dr Michael Conlon, a biochemist at the university in Abu Dhabi.
“They’ve been around 300 million years, so they’ve had plenty of time to learn how to defend themselves against disease-causing microbes in the environment.
“Their own environment includes polluted waterways where strong defences against pathogens are a must.”
Scientists have known for years that the skin of frogs is a rich source of chemicals capable of killing bacteria, viruses, and fungi.
Researchers have attempted to isolate those germ-fighting chemicals and make them suitable for development into new antibiotics.
Success, however, has been elusive because the antibiotics tend to be toxic to human cells and certain chemicals in the bloodstream easily destroy them.
Dr Conlon and colleagues have discovered a way to tweak their molecular structure, making them less toxic to human cells but more powerful germ killers.