The Obama administration does seem to be pushing the “settlement” issue harder than his predecessors, though; GWB had a written agreement with Israel that some of the “settlements” would be part of Israel after an agreement with the Palis, in return for other land. And they would be allowed to have “natural growth”.
The Cairo speech was vague, but other statements, largely from Hillary Clinton, that any expansion of “settlements” is not supposed to be allowed.

Of course, the Palis won’t be happy until all the “settlements” are removed, including “settlements” like Tel Aviv.