Nearly every creationist (who wants a physical Adam and Eve a la Genesis) I have read is ignorant of genetics and the discoveries of physical anthropology of the last several decades.

Put simply, it is impossible for every living male today to have descended from Noah.

It is also impossible for all humans to have descended from one male and one female (cocurrent with the former) 6000 years ago.

The genetic evidence for this is so overwhelming, that it is more decisive than the discoveries of Galileo et. al. about how wrong an Earth-centered creation was in describing our planet and everything else.