I have begun to figure out EUIV. Here is the state of my current playthrough as the Ottomans. February 1494.

I have only lost one war, allied with Morocco, against Castile and Portugal.

I have not yet conquered the Aegean, as I don’t want a chain reaction war against all of Italy and Iberia yet.

Me and Castile will eventually get into a bloody, knockdown war. But by then. I should control far more land.